Ritalinic acid explained
Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate, dexmethylphenidate and ethylphenidate.[1] [2] When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1).[3]
Etymologically, ritalinic acid shares its roots with Ritalin, a common brand name for methylphenidate.
Uses
Ritalinic acid is used as an intermediate in the synthesis of methylphenidate and its analogues, such as ethylphenidate and isopropylphenidate.
External links
Notes and References
- Faraj BA, Israili ZH, Perel JM, Jenkins ML, Holtzman SG, Cucinell SA, Dayton PG . Metabolism and disposition of methylphenidate-14C: studies in man and animals . The Journal of Pharmacology and Experimental Therapeutics . 191 . 3 . 535–47 . December 1974 . 4473537 .
- Negreira N, Erratico C, van Nuijs AL, Covaci A . Identification of in vitro metabolites of ethylphenidate by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry . Journal of Pharmaceutical and Biomedical Analysis . 117 . 5 . 474–84 . January 2016 . 26454340 . 10.1016/j.jpba.2015.09.029 . free . 10067/1301870151162165141 .
- Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF . 24233422 . 6 . Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1 . The Journal of Pharmacology and Experimental Therapeutics . 310 . 2 . 469–76 . August 2004 . 15082749 . 10.1124/jpet.104.067116 .
