Ribonuclease IV explained

Ribonuclease IV
Ec Number:3.1.26.6
Cas Number:61536-76-3

Ribonuclease IV (endoribonuclease IV, poly(A)-specific ribonuclease) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups

This enzyme forms oligonucleotides with an average chain length of 10.

Notes and References

  1. Müller WE . Endoribonuclease IV. A poly(A)-specific ribonuclease from chick oviduct. 1. Purification of the enzyme . European Journal of Biochemistry . 70 . 1 . 241–8 . November 1976 . 1009928 . 10.1111/j.1432-1033.1976.tb10975.x .
  2. Müller WE, Seibert G, Steffen R, Zahn RK . Endoribonuclease IV. 2. Further investigation on the specificity . European Journal of Biochemistry . 70 . 1 . 249–58 . November 1976 . 1009929 . 10.1111/j.1432-1033.1976.tb10976.x .