Ribonuclease (poly-(U)-specific) explained

Ribonuclease (poly-(U)-specific)
Ec Number:	3.1.26.9

Ribonuclease (poly-(U)-specific) (ribonuclease (uracil-specific), uracil-specific endoribonuclease, uracil-specific RNase) is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups

This enzyme forms oligonucleotides with chain lengths of 6 to 12.

Notes and References

1. Bachmann M, Trautmann F, Messer R, Zahn RK, Meyer zum Büschenfelde KH, Müller WE . Association of a polyuridylate-specific endoribonuclease with small nuclear ribonucleo-proteins which had been isolated by affinity chromatography using antibodies from a patient with systemic lupus erythematosus . European Journal of Biochemistry . 136 . 3 . 447–51 . November 1983 . 6227485 . 10.1111/j.1432-1033.1983.tb07762.x . free .