Retinyl acetate explained

Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.^{[1] [2]}

In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.^[3]

Toxicology

See also: Hypervitaminosis A. World Health Organization "Recommendations for preformed vitamin A supplements for mothers during pregnancy" states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000 IU vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinol and retinyl esters, such as retinyl palmitate and retinyl acetate.^[4]

Notes and References

1. 10.1038/267620a0 . Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea . 1977 . Moon . Richard C. . Grubbs . Clinton J. . Sporn . Michael B. . Goodman . Dawn G. . Nature . 267 . 5612 . 620–1 . 876383. 1977Natur.267..620M . 4211886 .
2. http://www.cancer.gov/drugdictionary?cdrid=40313 Retinyl acetate
3. https://www.fda.gov/Food/FoodIngredientsPackaging/GenerallyRecognizedasSafeGRAS/GRASSubstancesSCOGSDatabase/ucm261336.htm Select Committee on GRAS Substances (SCOGS) Opinion: Vitamin A
4. Book: World Health Organization Nutrition Unit . Safe vitamin A dosage during pregnancy and lactation . 1998 . World Health Organization . 10665/63838 . free .