Trihydroxystilbene synthase explained

trihydroxystilbene synthase
Ec Number:	2.3.1.95
Cas Number:	128449-70-7
Go Code:	0050350

In enzymology, a trihydroxystilbene synthase is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA

\rightleftharpoons 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO₂

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, 3,4',5-trihydroxy-stilbene (resveratrol), and CO₂.

This enzyme belongs to the family of transferases, To be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include resveratrol synthase, and stilbene synthase.^[1] This enzyme participates in phenylpropanoid biosynthesis.^[2]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes ^[3] and .

Further reading

• Schöppner A, Kindl H . Purification and properties of a stilbene synthase from induced cell suspension cultures of peanut . The Journal of Biological Chemistry . 259 . 11 . 6806–11 . June 1984 . 10.1016/S0021-9258(17)39799-5 . 6427224 . free .

Notes and References

1. Valletta. Alessio. Iozia. Lorenzo Maria. Leonelli. Francesca. January 2021. Impact of Environmental Factors on Stilbene Biosynthesis. Plants. en. 10. 1. 90. 10.3390/plants10010090. 33406721. 7823792. free.
2. Dubrovina. A. S.. Kiselev. K. V.. October 2017. Regulation of stilbene biosynthesis in plants. Planta. en. 246. 4. 597–623. 10.1007/s00425-017-2730-8. 28685295. 4015467. 0032-0935.
3. Shomura Y, Torayama I, Suh DY, Xiang T, Kita A, Sankawa U, Miki K . Crystal structure of stilbene synthase from Arachis hypogaea . Proteins . 60 . 4 . 803–6 . September 2005 . 16028220 . 10.1002/prot.20584 . 44490134 .