Renal tissue kallikrein explained

Tissue kallikrein
Ec Number:3.4.21.35
Cas Number:389069-73-2

Renal tissue kallikrein (glandular kallikrein, pancreatic kallikrein, submandibular kallikrein, submaxillary kallikrein, kidney kallikrein, urinary kallikrein, kallikrein, salivary kallikrein, kininogenin, kininogenase, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, depot-padutin, urokallikrein, dilminal D, onokrein P) is an enzyme.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18]

Renal tissue kallikrein is formed from kidney tissue prokallikrein by activation with the enzyme trypsin. It catalyses the chemical reaction causing preferential cleavage of Arg- bonds in small molecule substrates, acting to highly selectively release kallidin (lysyl-bradykinin, a bioactive kinin) from kininogen (a kinin protein precursor).

Notes and References

  1. Book: Fiedler F, Fink E, Tschesche H, Fritz H . Porcine glandular kallikreins . Proteolytic Enzymes, Part C . Methods in Enzymology . 80 Pt C . 493–532 . 1981 . 7043199 . 10.1016/s0076-6879(81)80042-0 . 978-0-12-181980-4 .
  2. Anundi H, Ronne H, Peterson PA, Rask L . Partial amino-acid sequence of the epidermal growth-factor-binding protein . European Journal of Biochemistry . 129 . 2 . 365–71 . December 1982 . 6295764 . 10.1111/j.1432-1033.1982.tb07059.x . free .
  3. Pesquero JL, Boschcov P, Oliveira MC, Paiva AC . Effect of substrate size on tonin activity . Biochemical and Biophysical Research Communications . 108 . 4 . 1441–6 . October 1982 . 6295383 . 10.1016/s0006-291x(82)80068-5 .
  4. Gutkowska J, Corvol P, Figueiredo AF, Inagami T, Bouhnik J, Genest J . Kinetic studies of rat renin and tonin on purified rat angiotensinogen . Canadian Journal of Biochemistry and Cell Biology . 62 . 2–3 . 137–42 . 1984 . 10.1139/o84-020 . 6097352 .
  5. Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S . Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins . Biochemical and Biophysical Research Communications . 127 . 1 . 289–95 . February 1985 . 3844939 . 10.1016/s0006-291x(85)80157-1 .
  6. Akiyama K, Nakamura T, Iwanaga S, Hara M . The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein . FEBS Letters . 225 . 1–2 . 168–72 . December 1987 . 3691800 . 10.1016/0014-5793(87)81151-1 . free . 1987FEBSL.225..168A .
  7. Evans BA, Drinkwater CC, Richards RI . Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus . The Journal of Biological Chemistry . 262 . 17 . 8027–34 . June 1987 . 10.1016/S0021-9258(18)47521-7 . free . 3036794 .
  8. Fiedler F . Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin . European Journal of Biochemistry . 163 . 2 . 303–12 . March 1987 . 3643848 . 10.1111/j.1432-1033.1987.tb10801.x . free .
  9. Fujinaga M, James MN . Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution . Journal of Molecular Biology . 195 . 2 . 373–96 . May 1987 . 2821276 . 10.1016/0022-2836(87)90658-9 .
  10. Kato H, Nakanishi E, Enjyoji K, Hayashi I, Oh-ishi S, Iwanaga S . Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes . Journal of Biochemistry . 102 . 6 . 1389–404 . December 1987 . 10.1093/oxfordjournals.jbchem.a122185 . 3482210 .
  11. Book: Bailey GS . Rat pancreas kallikrein . Immunochemical Techniques Part M: Chemotaxis and Inflammation . Methods in Enzymology . 163 . 115–28 . 1989 . 3237072 . 10.1016/0076-6879(88)63013-8 . 978-0-12-182064-0 .
  12. Blaber M, Isackson PJ, Marsters JC, Burnier JP, Bradshaw RA . Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland . Biochemistry . 28 . 19 . 7813–9 . September 1989 . 2611215 . 10.1021/bi00445a043 .
  13. Book: Chao J, Chao L . Rat urinary kallikrein . Immunochemical Techniques Part M: Chemotaxis and Inflammation . Methods in Enzymology . 163 . 128–43 . 1988 . 3070295 . 10.1016/0076-6879(88)63014-x . 978-0-12-182064-0 .
  14. Book: Geiger R, Miska W . [101 Human tissue kallikrein . Immunochemical Techniques Part M: Chemotaxis and Inflammation . Methods in Enzymology . 163 . 102–15 . 1988 . 3237071 . 10.1016/0076-6879(88)63012-6 . 978-0-12-182064-0 .
  15. Bertrand R, Derancourt J, Kassab R . Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C . FEBS Letters . 246 . 1–2 . 171–6 . March 1989 . 2523317 . 10.1016/0014-5793(89)80277-7 . free . 1989FEBSL.246..171B .
  16. Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ . Organization and expression of the rat kallikrein gene family . The Journal of Biological Chemistry . 264 . 13 . 7653–62 . May 1989 . 10.1016/S0021-9258(18)83284-7 . free . 2708383 .
  17. Elmoujahed A, Gutman N, Brillard M, Gauthier F . Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland . FEBS Letters . 265 . 1–2 . 137–40 . June 1990 . 2194829 . 10.1016/0014-5793(90)80903-v . free . 1990FEBSL.265..137E .
  18. Xiong W, Chen LM, Chao J . Purification and characterization of a kallikrein-like T-kininogenase . The Journal of Biological Chemistry . 265 . 5 . 2822–7 . February 1990 . 10.1016/S0021-9258(19)39875-8 . free . 2303430 .

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