Relaxin/insulin-like family peptide receptor 4 explained

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.^[1]

Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by [[OMIM]]]

See also

• Relaxin receptor

External links

• Web site: Relaxin Family Peptide Receptors: RXFP4 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303180217/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3037 . dead .

Further reading

• Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ . Receptors for relaxin family peptides . Annals of the New York Academy of Sciences . 1041 . 61–76 . May 2005 . 1 . 15956688 . 10.1196/annals.1282.010 . 2005NYASA1041...61B . 1185573 .
• Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ . International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides . Pharmacological Reviews . 58 . 1 . 7–31 . March 2006 . 16507880 . 10.1124/pr.58.1.9 . 7466039 .
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S . Identification of G protein-coupled receptor genes from the human genome sequence . FEBS Letters . 520 . 1–3 . 97–101 . June 2002 . 12044878 . 10.1016/S0014-5793(02)02775-8 . 7116392 .
• Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW . Identification of relaxin-3/INSL7 as a ligand for GPCR142 . The Journal of Biological Chemistry . 278 . 50 . 50765–70 . December 2003 . 14522967 . 10.1074/jbc.M308996200 . free .
• Boels K, Schaller HC . Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor . British Journal of Pharmacology . 140 . 5 . 932–8 . November 2003 . 14530218 . 1574110 . 10.1038/sj.bjp.0705521 .
• Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB . Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives . FEBS Letters . 554 . 3 . 381–8 . November 2003 . 14623098 . 10.1016/S0014-5793(03)01196-7 . 11563502 . free .
• Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW . Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7 . Molecular Pharmacology . 67 . 1 . 231–40 . January 2005 . 15465925 . 10.1124/mol.104.006700 . 25164369 .
• Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW . INSL5 is a high affinity specific agonist for GPCR142 (GPR100) . The Journal of Biological Chemistry . 280 . 1 . 292–300 . January 2005 . 15525639 . 10.1074/jbc.M409916200 . free .

Notes and References

1. Web site: Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4.