Regulation of chemicals explained

The regulation of chemicals is the legislative intent of a variety of national laws or international initiatives such as agreements, strategies or conventions. These international initiatives define the policy of further regulations to be implemented locally as well as exposure or emission limits. Often, regulatory agencies oversee the enforcement of these laws.

Chemicals are regulated for:

International initiatives

Strategic Approach to International Chemicals Management (SAICM) -.[1] This initiative was adopted at the International Conference on Chemicals Management (ICCM), which took place from 4–6 February 2006 in Dubai gathering Governments and intergovernmental and non-governmental organizations. It defines a policy framework to foster the sound worldwide management of chemicals. This initiative covers risk assessments of chemicals and harmonized labeling up to tackling obsolete and stockpiled products. Are included provisions for national centers aimed at helping in the developing world, train staff in chemical safety as well as dealing with spills and accidents. SAICM is a voluntary agreement. A second International Conference on Chemicals Management -ICCM2- held in May 2009 in Geneva took place in order to enhance synergies and cost effectiveness and to promote SAICM’s multi-sectorial nature.

Globally Harmonized System of Classification and Labeling of Chemicals (GHS)[<ref>{{cite web|url=http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html|title=About the GHS|work=unece.org}}</ref>]The “Globally Harmonized System of Classification and Labelling of Chemicals” (GHS) proposes harmonized hazard communication elements, including labels and safety data sheets. It was adopted by the United Nations Economic Commission for Europe (UNECE) in 2002. This system aims to ensure a better protection of human health and the environment during the handling of chemicals, including their transport and use. The classification of chemicals is done based on their hazard. This harmonization will facilitate trade when implemented entirely.

Stockholm Convention http://www.unido.org/index.php?id=5279- The Stockholm Convention is a global treaty to protect human health and the environment from persistent organic pollutants(POPs). It entered into force, on 17 May 2004, and over 150 countries signed the Convention. In May 2009, nine new chemicals are proposed for listing which then contained 12 substances.

Rotterdam Convention [2] – The objectives of the Rotterdam Convention are:

The text of the Convention was adopted on 10 September 1998 by a Conference in Rotterdam, the Netherlands. The Convention entered into force on 24 February 2004. The Convention creates legally binding obligations for the implementation of the Prior Informed Consent (PIC) procedure.

Basel Convention [3] –The Basel Convention on the Control of Trans-boundary Movements of Hazardous Wastes and their Disposal is a global environmental agreement on hazardous and other wastes. It came into force in 1992. The Convention has 172 Parties and aims to protect human health and the environment against the adverse effects resulting from the generation, management, transboundary movements and disposal of hazardous and other wastes.

Montreal Protocol[4] [5] – The Montreal Protocol was a globally coordinated regulatory action that sought to regulate ozone-depleting chemicals. 191 countries have ratified the treaty.

Global Framework on Chemicals - The plan was adopted on 30 September 2023 in Bonn at the fifth session of the International Conference on Chemicals Management organized by the UN Environment Programme (UNEP).[6]

Regional regulations

USA:[7] The Environmental Protection Agency (EPA) of the US announced in 2009 that the chemicals management laws would be strengthened, and that it would initiate a comprehensive approach to enhance the chemicals management program, including:

Chemicals are regulated under various laws including the Toxic Substances Control Act (TSCA). In 2010, Congress was considering a new law entitled the Safe Chemicals Act.[8] Over the following several years, the Senate considered a number of legislative texts to amend the TSCA. These included the Safer Chemicals Act, several versions of which were introduced by Senator Frank Lautenberg (D-NJ), with the latest in 2013, and the Chemical Safety Improvement Act (S. 1009, CSIA) introduced by Senators Lautenberg and David Vitter (R-LA) in 2013. Senator Lautenberg died shortly after CSIA's introduction, and over time his mantle was picked up by Senator Tom Udall (D-NM), who continued to work with Senator Vitter on revisions to the CSIA. The result of that effort was the Frank R. Lautenberg Chemical Safety for the 21st Century Act, passed by the Senate on December 17, 2015. The Toxic Substances Control Act (TSCA) Modernization Act of 2015 (H.R. 2576), passed the House of Representatives on June 23, 2015.[9] Revised legislation, which resolved differences between the House and Senate versions, was forwarded to the President on June 14, 2016.[10] President Obama signed the bill into law on June 22, 2016. The Senator's widow, Bonnie Lautenberg, was present at the White House signing ceremony.[11]

EU: Chemicals in Europe are managed by the REACH[12] [13] (Registration, Evaluation and Authorization and Restriction of Chemicals) and the CLP[14] (Classification, Labeling and Packaging) regulations. Specific regulations exist for specific families of products such as Fertilizers, Detergents, Explosives, Pyrotechnic Articles, Drug Precursors.[15]

Canada: In Canada, the Chemicals Management Plan [16] is responsible for designating priority chemicals, gathering public information about those chemicals, and generating risk assessment and management strategies.

Issues

A study suggests and defines a 'planetary boundary' for novel entities such as plastic- and chemical pollution and concluded that it has been crossed, suggesting – alongside many other studies and indicators – that more and improved regulations or related changes (e.g. enforcement- or trade-related changes) are necessary.[17] [18]

Using drug discovery artificial intelligence algorithms, researchers generated 40,000 potential chemical weapon candidates,[19] [20] which may be relevant to timely regulation of chemicals and related products that can be used to manufacture the fraction of viable candidates. According to a senior scientist author of the study, synthesizing these chemicals for real harm would be the more difficult part and certain needed molecules for doing so are known and regulated – however, some viable candidates may only require currently non-regulated compounds.[21]

Other issues include:

See also

Notes and References

  1. Web site: Week-end International du 5-6 juin 2010 . October 30, 2009 . dead . https://web.archive.org/web/20100909094851/http://saicm.org/ . September 9, 2010 .
  2. Web site: Rotterdam Convention Home Page. pic.int.
  3. Web site: Basel Convention Home Page. basel.int.
  4. Web site: Publications. unep.org.
  5. Web site: OZONE SECRETARIAT. unep.org.
  6. Web site: UN adopts new global rules to reduce chemicals harm . September 30, 2023 . dw.
  7. Web site: Chemicals under the Toxic Substances Control Act (TSCA) . 29 April 2015 .
  8. http://www.rsc.org/chemistryworld/News/2010/April/16041001.asp Congress proposes toxic chemical regulation reforms
  9. Web site: Recent Regulatory Developments Bergeson & Campbell. www.lawbc.com. 2016-02-14.
  10. Web site: HR 2576 Frank R. Lautenberg Chemical Safety for the 21st Century Act . Library of Congress . June 22, 2016 .
  11. News: Obama signs major overhaul of toxic chemicals rules into law . Associated Press . Lederman . Josh . June 22, 2016 . June 22, 2016.
  12. Web site: REACH - Chemicals - Environment - European Commission. europa.eu.
  13. Web site: Chemicals. europa.eu. 2009-11-10. https://web.archive.org/web/20091003165712/http://ec.europa.eu/enterprise/sectors/chemicals/index_en.htm. 2009-10-03. dead.
  14. Web site: CLP/GHS - Classification, labelling and packaging of substances and mixtures. europa.eu. dead. https://web.archive.org/web/20120414144231/http://ec.europa.eu/enterprise/sectors/chemicals/classification/index_en.htm. 2012-04-14.
  15. Web site: Specific Chemicals and GLP. europa.eu. 2009-11-10. https://web.archive.org/web/20091005071225/http://ec.europa.eu/enterprise/sectors/chemicals/specific-chemicals/index_en.htm. 2009-10-05. dead.
  16. Web site: Chemicals Management Plan. canada.ca. 2006-10-27.
  17. News: Chemical pollution has passed safe limit for humanity, say scientists . 12 February 2022 . The Guardian . 18 January 2022 . en.
  18. Persson . Linn . Carney Almroth . Bethanie M. . Collins . Christopher D. . Cornell . Sarah . de Wit . Cynthia A. . Diamond . Miriam L. . Fantke . Peter . Hassellöv . Martin . MacLeod . Matthew . Ryberg . Morten W. . Søgaard Jørgensen . Peter . Villarrubia-Gómez . Patricia . Wang . Zhanyun . Hauschild . Michael Zwicky . Outside the Safe Operating Space of the Planetary Boundary for Novel Entities . Environmental Science & Technology . 1 February 2022 . 56 . 3 . 1510–1521 . 10.1021/acs.est.1c04158 . 35038861 . 8811958 . 2022EnST...56.1510P . 0013-936X.
  19. News: Yirka . Bob . Repurposed drug-seeking AI system generates 40,000 possible chemical weapons in just six hours . 19 April 2022 . techxplore.com . en.
  20. Urbina . Fabio . Lentzos . Filippa . Invernizzi . Cédric . Ekins . Sean . Dual use of artificial-intelligence-powered drug discovery . Nature Machine Intelligence . March 2022 . 4 . 3 . 189–191 . 10.1038/s42256-022-00465-9 . 36211133 . 9544280 . 247302391 . en . 2522-5839 .
  21. News: AI drug algorithms can be flipped to generate bioweapons . 24 April 2022 . www.theregister.com . en.
  22. Web site: Doctor's Op-Ed: Consumers are losing trust in the supplements industry. Here's why we need to earn it back. . Nutritional Outlook . 24 April 2022 . en.
  23. News: Prohibited, unlisted, even dangerous ingredients turn up in dietary supplements . 24 April 2022 . Washington Post.
  24. Grohn . Kristopher J. . Moyer . Brandon S. . Wortel . Danique C. . Fisher . Cheyanne M. . Lumen . Ellie . Bianchi . Anthony H. . Kelly . Kathleen . Campbell . Paul S. . Hagrman . Douglas E. . Bagg . Roger G. . Clement . James . Wolfe . Aaron J. . Basso . Andrea . Nicoletti . Cristina . Lai . Giovanni . Provinciali . Mauro . Malavolta . Marco . Moody . Kelsey J. . C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice . GeroScience . 1 April 2021 . 43 . 2 . 579–591 . 10.1007/s11357-020-00292-z . 33123847 . 8110650 . 226206079 . en . 2509-2723.