| cholecystokinin A receptor | |
| Hgncid: | 1570 |
| Symbol: | CCKAR |
| Entrezgene: | 886 |
| Omim: | 118444 |
| Refseq: | NM_000730 |
| Uniprot: | P32238 |
| Chromosome: | 4 |
| Arm: | p |
| Band: | 15.2 |
| Locussupplementarydata: | -p15.1 |
| cholecystokinin B receptor | |
| Hgncid: | 1571 |
| Symbol: | CCKBR |
| Entrezgene: | 887 |
| Omim: | 118445 |
| Refseq: | NM_176875 |
| Uniprot: | P32239 |
| Chromosome: | 11 |
| Arm: | p |
| Band: | 15.4 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
| Protein | Gene | Tissue distribution | Preferred ligand | Function | Mechanism | |
|---|---|---|---|---|---|---|
| CCKA (CCK1) | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | Gq[3] [4] | ||
| CCKB (CCK2) | primarily CNS, lesser amounts in the gastrointestinal tract | gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger | Gq/G11 |