Rate of infusion explained

In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.

Abbreviations include K_in,^[1] K₀,^[2] or R₀.

It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:

style K _{in} = C _{ss} ⋅ CL

Notes and References

1. Web site: Cp vs time - iv infusion .
2. Web site: Chapter 15.2 - Continuous IV Infusion - Steady State .