RAF kinase explained

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.[1] The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.[2]

RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade.[1] Activation of RAF kinases requires interaction with RAS-GTPases.

The three RAF kinase family members are:

Notes and References

  1. Roskoski R . RAF protein-serine/threonine kinases: structure and regulation . Biochemical and Biophysical Research Communications . 399 . 3 . 313–317 . August 2010 . 20674547 . 10.1016/j.bbrc.2010.07.092 .
  2. Zebisch A, Troppmair J . Back to the roots: the remarkable RAF oncogene story . Cellular and Molecular Life Sciences . 63 . 11 . 1314–1330 . June 2006 . 16649144 . 10.1007/s00018-006-6005-y . 20116800 . 11136008 .

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