Quinoline 2-oxidoreductase explained
| quinoline 2-oxidoreductase |
| Ec Number: | 1.3.99.17 |
| Cas Number: | 132264-32-5 |
| Go Code: | 0018523 |
In enzymology, a quinoline 2-oxidoreductase is an enzyme that catalyzes the chemical reaction
quinoline + acceptor + H2O
quinolin-1(2H)-one + reduced acceptor
The 3 substrates of this enzyme are quinoline, acceptor, and H2O, whereas its two products are quinolin-1(2H)-one and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is quinoline:acceptor 2-oxidoreductase (hydroxylating).
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
References
- Bauder R, Tshisuaka B, Lingens F . 1990 . Microbial metabolism of quinoline and related compounds. VII Quinoline oxidoreductase from Pseudomonas putida: a molybdenum-containing enzyme . Biol. Chem. Hoppe-Seyler . 371 . 1137 - 44 . 2090161 . 12 . 10.1515/bchm3.1990.371.2.1137 .
- Tshisuaka B, Kappl R, Huttermann J, Lingens F . 1993 . Quinoline oxidoreductase from Pseudomonas putida 86: an improved purification procedure and electron paramagnetic resonance spectroscopy . Biochemistry . 32 . 12928 - 34 . 8251516 . 10.1021/bi00210a047 . 47 .
- Peschke B, Lingens F . 1991 . Microbial metabolism of quinoline and related compounds. XII Isolation and characterization of the quinoline oxidoreductase from Rhodococcus spec. B1 compared with the quinoline oxidoreductase from Pseudomonas putida 86 . Biol. Chem. Hoppe-Seyler . 372 . 1081 - 8 . 1789933 . 12 . 10.1515/bchm3.1991.372.2.1081 .
- Schach S, Tshisuaka B, Fetzner S, Lingens F . 1995 . Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation . Eur. J. Biochem. . 232 . 536 - 44 . 7556204 . 10.1111/j.1432-1033.1995.tb20841.x . 2 .
