See also: Kingdom of Cyprus.
Byzantine titles did not have any territorial qualification, so there were no Emperors or Despots of Cyprus.
| Unnamed | Thoros II, Prince of Armenia (Rubenids) | 1150–1164 | 1175/76 | 1184 became Despoina 1185 became Empress | before 1185 | Isaac Komnenos | ||
| Unnamed | William I of Sicily (Hauteville) | - | 1185/86 | 1 June 1191 Richard the Lionheart's conquest, husband's desposition | - | |||
| Eschive d'Ibelin | Baldwin d'Ibelin, Lord of Rama (Ibelin) | 1160 | before 29 October 1175 | 18 July 1194 husband's accession | Winter 1196–1197 | Amalric I | ||
| Isabella I of Jerusalem | Amalric I of Jerusalem (Anjou) | 1172 | January 1198 | 1 April 1205 husband's death | 5 April 1205 | |||
| Alice of Champagne | Henry II, Count of Champagne (Blois) | 1195/1196 | before September 1210 | 10 January 1218 husband's death | 1246 | Hugh I | ||
| Alix of Montferrat | William VI, Marquess of Montferrat (Aleramici) | 1210/1215 | May 1229 | December 1232-May 1233 | Henry I | |||
| Stephanie of Lampron | Constantine of Lampron, Lord of Barbaron and Partzerpert (Lampron) | 1220/1225 | before 17 November 1237 | 1 April/September 1249 | ||||
| Plaisance of Antioch | Bohemond V of Antioch (Ramnulfids) | 1235–1238 | September 1250 | 10 Jan 1253 husband's death | 27/22 September 1261 | |||
| Isabella d'Ibelin, Lady of Beirut | John II d'Ibelin, Lord of Beirut (Ibelin) | 1252 | 12 May 1265 | 5 December 1267 husband's death | before November 1283 | Hugh II | ||
| Isabella d'Ibelin [1] | Guy d'Ibelin, constable of Cyprus (Ibelin) | 1241/42 | after 23 January 1255 | 5 December 1267 husband's accession | 24 March 1284 husband's death | 2 June 1324 | Hugh III | |
| Constance of Sicily [2] | Frederick III of Sicily (Barcelona) | 1307 | 16 October 1317 | 31 August 1324 husband's death | after 19 June 1344 | Henry II | ||
| Alix d'Ibelin | Guy d'Ibelin, Lord of Nicosia (Ibelin) | 1304/06 | 18 Jun 1318 (date of Papal dispensation) | 31 March 1324 husband's accession | 24 November 1358 husband's abdication | after 6 August 1386 | Hugh IV | |
| Eleanor of Aragon [3] | Infante Pedro, Count of Ribagorça and Prades (Barcelona) | 1333 | September 1353 | 24 November 1358 husband's accession | 17 January 1369 husband's assassination | 26 December 1416 | Peter I | |
| Valentina Visconti | Bernabò Visconti (Visconti) | 1360/1362 | July/August 1378 | 13 October 1382 husband's death | before September 1393 | Peter II | ||
| Helvis of Brunswick-Grubenhagen [4] | Philip of Brunswick-Grubenhagen, Constable of Jerusalem (Welf) | 1353 | 1 May 1365 | 13 October 1382 husband's accession | 9 September 1398 husband's death | 15/25 January 1421 | James I | |
| Anglesia Visconti | Bernabò Visconti, Lord of Milan (Visconti) | 1377 | after January 1400 | 1407-1409 divorce | 12 October 1439 | Janus | ||
| Charlotte de Bourbon-La Marche | John I, Count of La Marche (Bourbon-La Marche) | 1388 | 25 August 1411 | 15 January 1422 | ||||
| Amadea Palaiologina of Monferrato | John Jacob Palaeologus, Marquess of Montferrat (Palaiologoi) | 1418/20 or 3 August 1429 | 3 July 1440 | 13 September 1440 | John II | |||
| Helena Palaiologina | Theodore II Palaiologos, Lord of Morea (Palaiologoi) | 3 February 1428 | 3 February 1442 | 11 April 1458 | ||||
| Louis of Savoy, Count of Geneva (also co-ruler) | Louis, Duke of Savoy (Savoy) | 5 June 1436 or 1 April 1437 | 4 October 1459 | 1464 wife's deposition | 16 July 1482 | Charlotte | ||
| Catherine Cornaro | Marco Cornaro (Cornaro) | 25 November 1454 | December 1472 | 10 July 1473 husband's death; later became regent then queen regnant | 10 July 1510 | James II | ||