Pyrrolobenzodiazepine Explained

Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.^[1]

Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.

History

Anthramycin, the first PBD monomer, was first synthesized in the 1960s.^[2]

Notes and References

1. Hartley JA . The development of pyrrolobenzodiazepines as antitumour agents . Expert Opinion on Investigational Drugs . 20 . 6 . 733–44 . June 2011 . 21457108 . 10.1517/13543784.2011.573477 . 26275418 .
2. 10.1002/anie.201510610 . From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs) . 2017 . Mantaj . Julia . Jackson . Paul J. M. . Rahman . Khondaker M. . Thurston . David E. . Angewandte Chemie International Edition . 56 . 2 . 462–488 . 27862776 . 5215561 .