Pyrrolidine dithiocarbamate explained

Pyrrolidine dithiocarbamate (PDTC) are a family of closely related drugs used for a metal chelation, induction of G1 phase cell cycle arrest,^[1] and preventing induction of nitric oxide synthase.^[2]

Pyrrolidine dithiocarbamate binds zinc such that the resulting complex can enter the cell and inhibit viral RNA-dependent RNA polymerase.^[3]

Reactions

Pyrrolidine dithiocarbamate, like other dithiocarbamates, forms coordination complexes with a variety of transition metals. One example is .^[4]

See also

• ionophore

Notes and References

1. 10.1002/jcp.10728 . 14603533 . PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21^Cip1 expression: Involvement of p38 mitogen activated protein kinase . Journal of Cellular Physiology . 198 . 2 . 310–23 . 2004 . Moon . Sung-Kwon . Jung . Sun-Young . Choi . Yung-Hyun . Lee . Young-Choon . Patterson . Cam . Kim . Cheorl-Ho .
2. http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=P8765|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC Ammonium pyrrolidinedithiocarbamate
3. Lanke . K. . Krenn . B. M. . Melchers . W. J. G. . Seipelt . J. . van Kuppeveld . F. J. M. . PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells . Journal of General Virology . 1 April 2007 . 88 . 4 . 1206–1217 . 10.1099/vir.0.82634-0. free .
4. 10.1021/ja00818a048. Structural Characterization of Tris(pyrrolidyldithiocarbamato)iron(IV) Perchlorate. Iron Sulfide (FeS₆) Complex of Unusually High Oxidation State . 1974 . Martin . R. L. . Rohde . N. M. . Robertson . G. B. . Taylor . D. . Journal of the American Chemical Society . 96 . 11 . 3647–3649 .