Pyrrole-2-carboxylate monooxygenase explained

Pyrrole-2-carboxylate monooxygenase
Ec Number:1.14.13.130

Pyrrole-2-carboxylate monooxygenase (pyrrole-2-carboxylate oxygenase) is an enzyme with systematic name pyrrole-2-carboxylate,NADH:oxygen oxidoreductase (5-hydroxylating).[1] [2] This enzyme catalyses the following chemical reaction

pyrrole-2-carboxylate + NADH + H+ + O2

\rightleftharpoons

5-hydroxypyrrole-2-carboxylate + NAD+ + H2O

Pyrrole-2-carboxylate monooxygenase is a flavoprotein (FAD).

Notes and References

  1. Hormann K, Andreesen JR . Purification and characterization of a pyrrole-2-carboxylate oxygenase from Arthrobacter strain Py1 . Biological Chemistry Hoppe-Seyler . 375 . 3 . 211–8 . March 1994 . 8011178 .
  2. Becker D, Schräder T, Andreesen JR . Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from Rhodococcus sp . European Journal of Biochemistry . 249 . 3 . 739–47 . November 1997 . 9395321 . 10.1111/j.1432-1033.1997.t01-1-00739.x . free .