Pyrithyldione Explained

Pyrithyldione^[1] (Presidon, Persedon) is a psychoactive drug invented in 1949.^[2] An improved method of manufacture was patented by Roche in 1959.^[3] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates.^[4] Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect.^{[5] [6]} Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide.^[7] In studies, it increased the O-demethylation of codeine by 20%.

See also

• Methyprylon
• Piperidione
• Glutethimide

Notes and References

1. US Patent 2090068 - 2,4-Dioxo-3,3-Dialkyl-Tetrahydropyridines and Process for the Manufacture of Same.
2. Becker EL, Fabing HD, Hawkins JR . Presidon; a new sedative-hypnotic . Christ Hospital Medical Bulletin . 2 . 4 . 80–4 . April 1949 . 18144514 .
3. US . patent . 3019230 . Hinderling R, Lutz AH, Schnider O . Hoffmann-La Roche . Method for the preparation of 2,4-dioxo-tetrahydropyridines . 1962-01-30 .
4. Pribilla . O. . 10.1007/BF00577351 . Zur Toxikologie des Persedons . Archiv für Toxikologie . 16 . 1. 34–49 . 1956 . 38210598 .
5. Ibáñez L, Ballarín E, Pérez E, Vidal X, Capellà D, Laporte JR . Agranulocytosis induced by pyrithyldione, a sedative hypnotic drug . European Journal of Clinical Pharmacology . 55 . 10 . 761–4 . January 2000 . 10663456 . 10.1007/s002280050011 . 25595314 .
6. Covner AH, Halpern SL . Fatal agranulocytosis following therapy with presidon (3,3-diethyl-2,4-dioxotetrahydropyridine) a new sedative hypnotic agent . The New England Journal of Medicine . 242 . 2 . 49–52 . January 1950 . 15399031 . 10.1056/NEJM195001122420203 .
7. Is pyrithyldione (Benedorm) an enzyme inducer (author's transl)