PncA explained

PncA is a gene encoding pyrazinamidase in Mycobacterium species.[1] Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid.[2] There is a strong correlation between mutations in pncA and resistance of M. tuberculosis to pyrazinamide.[3]

See also

Notes and References

  1. Scorpio A, Zhang Y . Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus . Nat. Med. . 2 . 6 . 662–7 . June 1996 . 8640557 . 10.1038/nm0696-662. 8579133 .
  2. Whitfield. Michael G.. Soeters. Heidi M.. Warren. Robin M.. York. Talita. Sampson. Samantha L.. Streicher. Elizabeth M.. Helden. Paul D. van. Rie. Annelies van. 2015-07-28. A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis. PLOS ONE. 10. 7. e0133869. 10.1371/journal.pone.0133869. 1932-6203. 4517823. 26218737. 2015PLoSO..1033869W. free.
  3. Juréen. Pontus. Werngren. Jim. Toro. Juan-Carlos. Hoffner. Sven. 2016-12-15. Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 52. 5. 1852–1854. 10.1128/AAC.00110-08. 0066-4804. 2346646. 18316515.

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