Pyranose dehydrogenase (acceptor) explained

Pyranose dehydrogenase (acceptor)
Ec Number:	1.1.99.29
Cas Number:	190606-21-4

Pyranose dehydrogenase (acceptor) (pyranose dehydrogenase, pyranose-quinone oxidoreductase, quinone-dependent pyranose dehydrogenase, PDH) is an enzyme with systematic name pyranose:acceptor oxidoreductase.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

(1) a pyranose + acceptor

\rightleftharpoons a pyranos-2-ulose (or a pyranos-3-ulose or a pyranos-2,3-diulose) + reduced acceptor

(2) a pyranoside + acceptor

\rightleftharpoons a pyranosid-3-ulose (or a pyranosid-3,4-diulose) + reduced acceptor

This enzyme requires FAD. A number of aldoses and ketoses in pyranose form, as well as glycosides, gluco-oligosaccharides, sucrose and lactose can act as a donor.

Notes and References

1. Volc J, Kubatova E, Wood DA, Daniel G . Pyranose 2-dehydrogenase, a novel sugar oxidoreductase from the basidiomycete fungus Agaricus bisporus . Archives of Microbiology . 167 . 2/3 . 119–25 . March 1997 . 9042751 . 10.1007/s002030050424 .
2. Volc J, Sedmera P, Halada P, Přikrylova V, Daniel G . C-2 and C-3 oxidation of D-Glc, and C-2 oxidation of D-Gal by pyranose dehydrogenase from Agaricus bisporus . Carbohydr. Res. . 1998 . 310 . 151–156 . 10.1016/s0008-6215(98)00151-7.
3. Volc J, Sedmera P, Halada P, Prikrylová V, Haltrich D . Double oxidation of D-xylose to D-glycero -pentos-2,3-diulose (2,3-diketo-D-xylose) by pyranose dehydrogenase from the mushroom Agaricus bisporus . Carbohydrate Research . 329 . 1 . 219–25 . October 2000 . 11086703 . 10.1016/s0008-6215(00)00167-1 .
4. Volc J, Kubátová E, Daniel G, Sedmera P, Haltrich D . Screening of basidiomycete fungi for the quinone-dependent sugar C-2/C-3 oxidoreductase, pyranose dehydrogenase, and properties of the enzyme from Macrolepiota rhacodes . Archives of Microbiology . 176 . 3 . 178–86 . September 2001 . 11511865 . 10.1007/s002030100308 .
5. Volc J, Sedmera P, Halada P, Daniel G, Přikrylová V, Haltrich D . C-3 oxidation of non-reducing sugars by a fungal pyranose dehydrogenase: spectral characterization . J. Mol. Catal., B Enzym. . 2002 . 17 . 91–100 . 10.1016/s1381-1177(02)00014-0.