Pyr-T Explained

Pyr-T (N,N-tetramethylenetryptamine) is a lesser-known, possible psychedelic drug. Pyr-T was first characterized by S. Mitzal.^[1] Toxicity testing was later performed by Hunt and Brimblecombe, and although a lethal dosage was found in rats, a value is not given.^[2] In the book TiHKAL (Tryptamines I Have Known and Loved), neither the dosage nor the duration are reported.^{[3] [4]}

Pyr-T produces few to no effects in humans, but some behavioral changes were observed in animal tests. Very little data exists about the pharmacological properties, metabolism, and toxicity of pyr-T.

See also

• 4-HO-pyr-T
• 5-MeO-pyr-T
• MPMI
• SN-22
• Tryptamine
• Psychedelics, dissociatives and deliriants

Notes and References

1. Mitzal. S.. N/A. Dissertationes Pharm.. 1962. 14. 305.
2. Hunt. R. R.. Brimblecombe. R. W.. Synthesis and Biological Activity of Some Ring-Substituted Tryptamines. Journal of Medicinal Chemistry. July 1967. 10. 4. 646–648. 10.1021/jm00316a027. 4962512. Hunt.
3. Book: Shulgin. Alexander. Shulgin. Ann. TiHKAL, The Continuation. 1997. Transform Press. Berkeley, CA, USA. 0-9630096-9-9. 577–578. 1st. 7 April 2018. HardcopyTiHKAL.
4. Krasowski MD, Ekins S. Using cheminformatics to predict cross reactivity of “designer drugs” to their currently available immunoassays. J Cheminform 6, 22 (2014).