Putrescine aminotransferase explained

Putrescine aminotransferase
Ec Number:	2.6.1.82
Cas Number:	98982-73- Science

Putrescine aminotransferase (putrescine-alpha-ketoglutarate transaminase, YgjG, putrescine:alpha-ketoglutarate aminotransferase, PAT, putrescine:2-oxoglutarate aminotransferase, putrescine transaminase) is an enzyme with systematic name butane-1,4-diamine:2-oxoglutarate aminotransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

\rightleftharpoons 1-pyrroline + L-glutamate + H₂O (overall reaction)

(1a) putrescine + 2-oxoglutarate

\rightleftharpoons 4-aminobutanal + L-glutamate

(1b) 4-aminobutanal

\rightleftharpoons 1-pyrroline + H₂O (spontaneous)

This enzyme is a pyridoxal-phosphate protein.

Notes and References

1. Prieto-Santos MI, Martín-Checa J, Balaña-Fouce R, Garrido-Pertierra A . A pathway for putrescine catabolism in Escherichia coli . Biochimica et Biophysica Acta (BBA) - General Subjects . 880 . 2–3 . 242–4 . February 1986 . 3510672 . 10.1016/0304-4165(86)90085-1 .
2. Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR . Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase . FEBS Letters . 579 . 19 . 4107–12 . August 2005 . 16023116 . 10.1016/j.febslet.2005.06.038 . free .
3. Samsonova NN, Smirnov SV, Altman IB, Ptitsyn LR . Molecular cloning and characterization of Escherichia coli K12 ygjG gene . BMC Microbiology . 3 . 1 . 2 . January 2003 . 10.1186/1471-2180-3-2 . 12617754 . 150594 . free .