Pustulosis palmaris et plantaris explained

Pustulosis palmaris et plantaris
Synonyms:Pustulosis of palms and soles,[1] Palmoplantar pustulosis, Persistent palmoplantar pustulosis, Pustular psoriasis of the Barber type, and Pustular psoriasis of the extremities
Differential:SAPHO syndrome

Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils.[2] [3] It can occur as part of the SAPHO syndrome.[4]

Treatment

Systematic reviews show evidence to support the use of systemic retinoids alone and in combination with photochemotherapy to improve symptoms of chronic palmoplantar pustulosis, with a combination more effective than one alone. There is also evidence to support topical steroids under hydrocolloid occlusion dressings, low dose ciclosporin, tetracyclines, and Grenz-Ray Therapy. There is no evidence to support the use of hydroxyurea in chronic palmoplantar pustulosis.[5]

Treatment with guselkumab, an anti–interleukin 23 monoclonal antibody has shown a decrease in the size of the area affected and severity.[6]

See also

Notes and References

  1. Book: Rapini . Ronald P. . Bolognia . Jean L. . Jorizzo . Joseph L. . vanc . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
  2. Book: Irwin M . Freedberg . Thomas B . Fitzpatrick . vanc . 2003 . Fitzpatrick's Dermatology in General Medicine . 6th . McGraw-Hill . 0-07-138076-0 .
  3. Book: James . William . Berger . Timothy . Elston . Dirk . vanc . 2005 . Andrews' Diseases of the Skin: Clinical Dermatology . 10th . Saunders . 0-7216-2921-0. .
  4. Matzaroglou C, Velissaris D, Karageorgos A, Marangos M, Panagiotopoulos E, Karanikolas M . SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature . The Open Orthopaedics Journal . 3 . 100–6 . November 2009 . 19997538 . 2790148 . 10.2174/1874325000903010100 . free.
  5. Chalmers. Robert. Hollis. Sally. Leonardi-Bee. Jo. Griffiths. Christopher EM. Marsland Bsc MRCP. Alexander. 2006-01-25. Interventions for chronic palmoplantar pustulosis. Cochrane Database of Systematic Reviews. 2016 . 1. CD001433. 10.1002/14651858.cd001433.pub2. 16437433. 26948658 . 1465-1858. 8958875.
  6. Terui T, Kobayashi S, Okubo Y, Murakami M, Zheng R, Morishima H, Goto R, Kimura T . 6 . Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial . JAMA Dermatology . 155 . 10 . 1153 . July 2019 . 31268476 . 6613288 . 10.1001/jamadermatol.2019.1394 .

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