Large cell neuroendocrine carcinoma of the lung explained

Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large-cell lung carcinoma.

LCNEC is often generically grouped among the non-small-cell lung carcinomas.^[1]

LCNECs often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%).^[2]

Variants

The World Health Organization classification of lung tumors^[1] recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC).

External links

• Lung Cancer Home Page. The National Cancer Institute site containing further reading and resources about lung cancer.
• https://web.archive.org/web/20110721001056/http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.

Notes and References

1. Book: Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart . Travis . William D . Brambilla . Elisabeth . Muller-Hermelink . H Konrad . 3 . Harris . Curtis C . IARC Press . Lyon . 2004 . World Health Organization Classification of Tumours . 978-92-832-2418-1 . 27 March 2010 . https://web.archive.org/web/20090823210304/http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-cover.pdf . 23 August 2009 . dead .
2. George . Walter . Peifer . Alexandrov . Seidel . Leenders . Maas . Müller . Dahmen . Delhomme . Ardin. Leblay. Byrnes . 4. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors . Nature Communications . 2018 . 9 . Article number: 1048 . 1048 . 10.1038/s41467-018-03099-x . 29535388 . 5849599 . 2018NatCo...9.1048G .