Pteridine reductase explained

Pteridine reductase
Ec Number:	1.5.1.33
Cas Number:	131384-61-7

In enzymology, a pteridine reductase is an enzyme that catalyzes the chemical reaction

5,6,7,8-tetrahydrobiopterin + 2 NADP⁺

\rightleftharpoons biopterin + 2 NADPH + 2 H⁺

Thus, the two substrates of this enzyme are 5,6,7,8-tetrahydrobiopterin and NADP⁺, whereas its 3 products are biopterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and .

References

• Nare B, Hardy LW, Beverley SM . 1997 . The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major . J. Biol. Chem. . 272 . 13883 - 91 . 9153248 . 10.1074/jbc.272.21.13883 . 21 . free .
• Gourley DG, Schüttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN . 2001 . Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites . Nat. Struct. Biol. . 8 . 521 - 5 . 11373620 . 10.1038/88584 . 6 . 32379320 .
• Book: Fitzpatrick PF . The Aromatic Amino Acid Hydroxylases . Advances in Enzymology and Related Areas of Molecular Biology . 2000 . Adv. Enzymol. Relat. Areas Mol. Biol. . 74 . 235 - 94 . 10800597 . 10.1002/9780470123201.ch6 . Advances in Enzymology - and Related Areas of Molecular Biology . 978-0-470-12320-1 .