Pseudaminic acid cytidylyltransferase explained

Pseudaminic acid cytidylyltransferase
Ec Number:	2.7.7.81

Pseudaminic acid cytidylyltransferase (PseF) is an enzyme with systematic name CTP:5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid cytidylyltransferase.^[1] This enzyme catalyses the following chemical reaction

CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid

\rightleftharpoons diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid

Mg²⁺ is required for activity.

Notes and References

1. Schoenhofen IC, McNally DJ, Brisson JR, Logan SM . Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction . Glycobiology . 16 . 9 . 8C-14C . September 2006 . 16751642 . 10.1093/glycob/cwl010 . free .