Proxibarbital Explained

Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and is, in contrast to most barbiturates, almost without hypnotic action.^[1]

It was also used in the treatment of migraine headaches in a similar manner to butalbital.^[2]

Valofane isomerises to Proxibarbal in vivo.

Notes and References

1. Book: Zejc A, Gorczyca M . Zajdel P, Kulig K, Zejc A . Drug chemistry, textbook for pharmacy students and pharmacists . Chemia leków, podręcznik dla studentów farmacji i farmaceutów . polish . 2008. Warszawa, Poland . 978-83-200-3652-7 .
2. Sulman FG, Pfeifer Y, Tal E . [Migraine therapy by enzyme induction with proxibarbital] . German . Therapie der Gegenwart . 115 . 12 . 2088–103 . December 1976 . 14412 .