Protostadienol synthase explained

Protostadienol synthase
Ec Number:	5.4.99.32

Protostadienol synthase (PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene

\rightleftharpoons (17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.

Notes and References

1. Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP . Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus . Organic Letters . 11 . 6 . 1241–4 . March 2009 . 19216560 . 10.1021/ol802696a .