Protoporphyrinogen IX dehydrogenase (menaquinone) explained

Protoporphyrinogen IX dehydrogenase (menaquinone)
Ec Number:	1.3.5.3

Protoporphyrinogen IX dehydrogenase (menaquinone) (HemG) is an enzyme with systematic name protoporphyrinogen IX:menaquinone oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons protoporphyrin IX + 3 menaquinol

This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments.

Notes and References

1. Boynton TO, Daugherty LE, Dailey TA, Dailey HA . Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity . Biochemistry . 48 . 29 . 6705–11 . July 2009 . 19583219 . 2749469 . 10.1021/bi900850y .