Protocatechuic aldehyde explained

Protocatechuic aldehyde is a phenolic aldehyde, a compound released from cork stoppers into wine.^[1]

This molecule can be used as a precursor in the vanillin synthesis by biotransformation by cell cultures of Capsicum frutescens, a type of Chili pepper.^[2] It is also found in the mushroom Phellinus linteus.^[3]

Pharmacological effects

Protocatechuic aldehyde regulates G protein-coupled estrogen receptor-1 (GPER-1) and exhibits protective effects in endothelial dysfunction and atherosclerosis.^[4]

See also

• Phenolic compounds in wine

Notes and References

1. Conde E, Cadahía E, García-Vallejo MC, Fernández de Simón B . Polyphenolic Composition of Quercus suber Cork from Different Spanish Provenances. . Journal of Agricultural and Food Chemistry . August 1998 . 46 . 8 . 3166–71 . 10.1021/jf970863k .
2. Rao SR, Ravishankar GA . Biotransformation of protocatechuic aldehyde and caffeic acid to vanillin and capsaicin in freely suspended and immobilized cell cultures of Capsicum frutescens . Journal of Biotechnology . 76 . 2–3 . 137–46 . January 2000 . 10656328 . 10.1016/s0168-1656(99)00177-7 . 28017446 .
3. Lee YS, Kang YH, Jung JY, Lee S, Ohuchi K, Shin KH, Kang IJ, Park JH, Shin HK, Lim SS . 6 . Protein glycation inhibitors from the fruiting body of Phellinus linteus . Biological & Pharmaceutical Bulletin . 31 . 10 . 1968–72 . October 2008 . 18827365 . 10.1248/bpb.31.1968 . free .
4. Kong BS, Cho YH, Lee EJ . G protein-coupled estrogen receptor-1 is involved in the protective effect of protocatechuic aldehyde against endothelial dysfunction . PLOS ONE . 9 . 11 . e113242 . 2014 . 25411835 . 4239058 . 10.1371/journal.pone.0113242 . 2014PLoSO...9k3242K . free .