Tyrosine-protein kinase Yes explained

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.^{[1] [2]}

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.^[2]

Interactions

YES1 has been shown to interact with Janus kinase 2,^[3] CTNND1,^[4] RPL10^[5] and Occludin.^[6]

Further reading

• Brickell PM . The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. . Critical Reviews in Oncogenesis . 3 . 4 . 401–46 . 1992 . 1384720 .
• Toyoshima K, Semba K, Nishizawa M, etal . Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family. . Int. Symp. Princess Takamatsu Cancer Res. Fund . 17 . 11–20 . 1988 . 3332005 .
• Sudol M, Chen HI, Bougeret C, etal . Characterization of a novel protein-binding module--the WW domain. . FEBS Lett. . 369 . 1 . 67–71 . 1995 . 7641887 . 10.1016/0014-5793(95)00550-S . 20664267 . free .
• Summy JM, Sudol M, Eck MJ, etal . Specificity in signaling by c-Yes. . Front. Biosci. . 8 . 6. s185–205 . 2004 . 12456296 . 10.2741/1011 . free .
• Cichowski K, McCormick F, Brugge JS . p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. . J. Biol. Chem. . 267 . 8 . 5025–8 . 1992 . 10.1016/S0021-9258(18)42721-4 . 1544885 . free .
• Huang MM, Bolen JB, Barnwell JW, etal . Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. . Proc. Natl. Acad. Sci. U.S.A. . 88 . 17 . 7844–8 . 1991 . 1715582 . 10.1073/pnas.88.17.7844 . 52400 . 1991PNAS...88.7844H . free .
• Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H . Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. . Proc. Natl. Acad. Sci. U.S.A. . 88 . 23 . 10411–5 . 1992 . 1720539 . 10.1073/pnas.88.23.10411 . 52938 . 1991PNAS...8810411H . free .
• Krueger J, Zhao YH, Murphy D, Sudol M . Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. . Oncogene . 6 . 6 . 933–40 . 1991 . 2067846 .
• Zhao YH, Krueger JG, Sudol M . Expression of cellular-yes protein in mammalian tissues. . Oncogene . 5 . 11 . 1629–35 . 1991 . 2267131 .
• Sukegawa J, Semba K, Yamanashi Y, etal . Characterization of cDNA clones for the human c-yes gene. . Mol. Cell. Biol. . 7 . 1 . 41–7 . 1987 . 2436037 . 10.1128/MCB.7.1.41. 365039 .
• Bull HA, Brickell PM, Dowd PM . Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells. . FEBS Lett. . 351 . 1 . 41–4 . 1994 . 7521304 . 10.1016/0014-5793(94)00814-0 . 45071719 . free .
• Toshima J, Ohashi K, Iwashita S, Mizuno K . Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. . Biochem. Biophys. Res. Commun. . 209 . 2 . 656–63 . 1995 . 7537495 . 10.1006/bbrc.1995.1549 .
• Courtneidge SA, Dhand R, Pilat D, etal . Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. . EMBO J. . 12 . 3 . 943–50 . 1993 . 7681396 . 10.1002/j.1460-2075.1993.tb05735.x. 413295 .
• Mori S, Rönnstrand L, Yokote K, etal . Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. . EMBO J. . 12 . 6 . 2257–64 . 1993 . 7685273 . 10.1002/j.1460-2075.1993.tb05879.x. 413454 .
• Waltenberger J, Claesson-Welsh L, Siegbahn A, etal . Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. . J. Biol. Chem. . 269 . 43 . 26988–95 . 1994 . 10.1016/S0021-9258(18)47116-5 . 7929439 . free .
• Silverman GA, Kuo WL, Taillon-Miller P, Gray JW . Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. . Genomics . 15 . 2 . 442–5 . 1993 . 8449516 . 10.1006/geno.1993.1086 .

Notes and References

1. Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K . Location of the c-yes gene on the human chromosome and its expression in various tissues . Science . 227 . 4690 . 1038–40 . Mar 1985 . 2983418 . 10.1126/science.2983418 . 1985Sci...227.1038S .
2. Web site: Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1.
3. Fuhrer . D K . Yang Y C . Jul 1996 . Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11 . Biochem. Biophys. Res. Commun. . 224 . 2 . 289–96 . 0006-291X. 8702385 . 10.1006/bbrc.1996.1023 .
4. Piedra . Jose . Miravet Susana . Castaño Julio . Pálmer Héctor G . Heisterkamp Nora . García de Herreros Antonio . Duñach Mireia . Apr 2003 . p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction . Mol. Cell. Biol. . 23 . 7 . 2287–97 . 0270-7306. 12640114 . 10.1128/MCB.23.7.2287-2297.2003 . 150740 .
5. Oh . Hyung Suk . Kwon Haeyoung . Sun Suk Kyun . Yang Chul-Hak . Sep 2002 . QM, a putative tumor suppressor, regulates proto-oncogene c-yes . J. Biol. Chem. . 277 . 39 . 36489–98 . 0021-9258. 12138090 . 10.1074/jbc.M201859200 . free .
6. Chen . Yan-Hua . Lu Qun . Goodenough Daniel A . Jeansonne Beverly . Apr 2002 . Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells . Mol. Biol. Cell . 13 . 4 . 1227–37 . 1059-1524. 11950934 . 10.1091/mbc.01-08-0423 . 102264 .