Protein geranylgeranyltransferase type I explained

CAAX-protein geranylgeranyltransferase
Ec Number:	2.5.1.59
Go Code:	0004662

In enzymology, a protein geranylgeranyltransferase type I is an enzyme that catalyzes the chemical reaction

geranylgeranyl diphosphate + protein-cysteine

\rightleftharpoons S-geranylgeranyl-protein + diphosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.

Structural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,, and .

References

• Casey PJ, Seabra MC . 1996 . Protein prenyltransferases . J. Biol. Chem. . 271 . 5289 - 92 . 8621375 . 10.1074/jbc.271.10.5289 . 10 . free .
• Zhang FL, Casey PJ . Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I . Biochem. J. . 1996. 320 . 925 - 32 . 9003382 . 1218017 . Pt 3 . 10.1042/bj3200925.
• Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.