Protein-ribulosamine 3-kinase explained

Protein-ribulosamine 3-kinase
Ec Number:	2.7.1.172

Protein-ribulosamine 3-kinase (FN3KRP, FN3K-related protein, FN3K-RP, ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-ribulosyl-L-lysine 3-phosphotransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

ATP + [protein]-N⁶-D-ribulosyl-L-lysine

\rightleftharpoons ADP + [protein]-N⁶-(3-O-phospho-D-ribulosyl)-L-lysine

This enzyme takes part in freeing proteins from ribulosamines or psicosamines.

Notes and References

1. Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E . A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines . Diabetes . 52 . 12 . 2888–95 . December 2003 . 14633848 . 10.2337/diabetes.52.12.2888 . free .
2. Fortpied J, Gemayel R, Stroobant V, van Schaftingen E . Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme . The Biochemical Journal . 388 . Pt 3 . 795–802 . June 2005 . 15705060 . 1183458 . 10.1042/BJ20041976 .
3. Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM . Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine . The Biochemical Journal . 416 . 2 . 281–8 . December 2008 . 18637789 . 10.1042/BJ20080389 .