Protein-histidine pros-kinase explained

protein histidine pros-kinase
Ec Number:	2.7.13.1
Cas Number:	99283-67-7
Go Code:	0008256

In enzymology, a protein-histidine pros-kinase is an enzyme that catalyzes the chemical reaction

ATP + protein L-histidine

\rightleftharpoons ADP + protein N^π-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-pros-phosphotransferase, histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK2.

References

• Fujitaki JM, Fung G, Oh EY, Smith RA . 1981 . Characterization of chemical enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance . Biochemistry . 20 . 3658 - 64 . 7196259 . 10.1021/bi00515a055 . 12 .
• Huebner VD, Matthews HR . 1985 . Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia . J. Biol. Chem. . 260 . 16106 - 13 . 4066704 . 30 .