Protein-glutamine glutaminase explained

protein-glutamine glutaminase
Ec Number:	3.5.1.44
Cas Number:	62213-11-0
Go Code:	0050568

In enzymology, a protein-glutamine glutaminase is an enzyme that catalyzes the chemical reaction

protein L-glutamine + H₂O

\rightleftharpoons protein L-glutamate + NH₃

Thus, the two substrates of this enzyme are protein L-glutamine and H₂O, whereas its two products are protein L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is protein-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase II, glutaminyl-peptide glutaminase, destabilase, and peptidylglutaminase II.

References

• Kikuchi M, Hayashida H, Nakano E, Sakaguchi K . 1971 . Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine . Biochemistry . 10 . 1222 - 9 . 4928623 . 10.1021/bi00783a019 . 7 .