Proteasome ATPase explained

Proteasome ATPase
Ec Number:	3.6.4.8

In enzymology, a proteasome ATPase is an enzyme that catalyzes the chemical reaction

ATP + H₂O

\rightleftharpoons ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (polypeptide-degrading).

References

• Rivett AJ, Mason GG, Murray RZ, Reidlinger J . 1997 . Regulation of proteasome structure and function . Mol. Biol. Rep. . 24 . 99 - 102 . 9228289 . 10.1023/A:1006814306401 . 1–2 .
• Mason GG, Murray RZ, Pappin D, Rivett AJ . 1998 . Phosphorylation of ATPase subunits of the 26S proteasome . FEBS Lett. . 430 . 269 - 74 . 9688553 . 10.1016/S0014-5793(98)00676-0 . 3 . free .