Prosultiamine Explained

Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B₁ deficiency.^{[1] [2] [3]} It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.^{[4] [5]}

Research

It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.^[6]

See also

• Vitamin B₁ analogue

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 3-88763-075-0 .
2. Book: Triggle DJ . Dictionary of pharmacological agents . Chapman & Hall . London . 1997 . 0-412-46630-9 .
3. 10.1093/oxfordjournals.jbchem.a126421. "allithiamine" A Newly Found Derivative of Vitamin B1. The Journal of Biochemistry. 41. 29–39. 1954. Fujiwara M, Watanabe H, Matsui K .
4. Thomson AD, Frank O, Baker H, Leevy CM . Thiamine propyl disulfide: absorption and utilization . Annals of Internal Medicine . 74 . 4 . 529–534 . April 1971 . 5551161 . 10.7326/0003-4819-74-4-529 .
5. Baker H, Frank O . Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines . Journal of Nutritional Science and Vitaminology . 22 SUPPL . 63–68 . August 1976 . 978282 . 10.3177/jnsv.22.supplement_63 . free .
6. Web site: Nervous System Disease: A New Outlet for an Old Drug? . 15 August 2013 . Science Daily .