Prostamide/prostaglandin F2alpha synthase explained

Prostamide/prostaglandin F2alpha synthase
Ec Number:	1.11.1.20

Prostamide/prostaglandin F2alpha synthase (prostamide/PGF synthase, prostamide F synthase, prostamide/prostaglandin F synthase, tPGF synthase) is an enzyme with systematic name thioredoxin:(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate oxidoreductase .^{[1] [2]} This enzyme catalyses the following chemical reaction

thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate

\rightleftharpoons thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate

This enzyme contains a thioredoxin-type disulfide as a catalytic group.

Notes and References

1. Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K . Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily . The Journal of Biological Chemistry . 283 . 2 . 792–801 . January 2008 . 18006499 . 10.1074/jbc.M705638200 . free .
2. Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A . Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system . Brain Research . 1367 . 22–32 . January 2011 . 20950588 . 10.1016/j.brainres.2010.10.019 .