Proteasome endopeptidase complex explained

Proteasome endopeptidase complex
Ec Number:	3.4.25.1
Cas Number:	140879-24-9
Width:	270

Proteasome endopeptidase complex (ingensin, macropain, multicatalytic endopeptidase complex, prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Cleavage of peptide bonds with very broad specificity

This 20-S protein is composed of 28 subunits arranged in four rings of seven.

Notes and References

1. Seemüller E, Lupas A, Stock D, Löwe J, Huber R, Baumeister W . Proteasome from Thermoplasma acidophilum: a threonine protease . Science . 268 . 5210 . 579–82 . April 1995 . 7725107 . 10.1126/science.7725107 . 1995Sci...268..579S .
2. Coux O, Tanaka K, Goldberg AL . Structure and functions of the 20S and 26S proteasomes . Annual Review of Biochemistry . 65 . 801–47 . 1996 . 8811196 . 10.1146/annurev.bi.65.070196.004101 .
3. Groll M, Ditzel L, Löwe J, Stock D, Bochtler M, Bartunik HD, Huber R . Structure of 20S proteasome from yeast at 2.4 A resolution . Nature . 386 . 6624 . 463–71 . April 1997 . 9087403 . 10.1038/386463a0 . 1997Natur.386..463G . 4261663 .
4. Dick TP, Nussbaum AK, Deeg M, Heinemeyer W, Groll M, Schirle M, Keilholz W, Stevanović S, Wolf DH, Huber R, Rammensee HG, Schild H . Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants . The Journal of Biological Chemistry . 273 . 40 . 25637–46 . October 1998 . 9748229 . 10.1074/jbc.273.40.25637 . free .