Prosolanapyrone-II oxidase explained

Prosolanapyrone-II oxidase
Ec Number:	1.1.3.42

Prosolanapyrone-II oxidase (Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cycloisomerase), prosolanapyrone II oxidase) is an enzyme with systematic name prosolanapyrone-II:oxygen 3'-oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

prosolanapyrone II + O₂

\rightleftharpoons prosolanapyrone III + H₂O₂

This enzyme participates in the biosynthesis of the phytotoxin solanapyrone by some fungi.

Notes and References

1. Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I . Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani . ChemBioChem . 11 . 9 . 1245–52 . June 2010 . 20486243 . 10.1002/cbic.201000173 .
2. Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A . Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 1384 . 2 . 387–95 . May 1998 . 9659400 . 10.1016/s0167-4838(98)00040-5 .
3. Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H . Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani . Bioscience, Biotechnology, and Biochemistry . 72 . 2 . 604–7 . February 2008 . 18256508 . 10.1271/bbb.70600 . free .