Propanoyl-CoA C-acyltransferase explained

Propanoyl-CoA C-acyltransferase
Ec Number:	2.3.1.176

In enzymology, a propanoyl-CoA C-acyltransferase is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA

\rightleftharpoons CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA and propanoyl-CoA, whereas its two products are CoA and 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase. Other names in common use include peroxisomal thiolase 2, sterol carrier protein-, SCP, and PTE-2 (ambiguous). This enzyme participates in ppar signaling pathway.

Propanoyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

References

• Pedersen JI, Gustafsson J . 1980 . Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes . FEBS Lett. . 121 . 345 - 8 . 7461136 . 2 . 10.1016/0014-5793(80)80377-2 . free .
• Kase F, Bjorkhem I, Pedersen JI . 1983 . Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes . J. Lipid Res. . 24 . 1560 - 7 . 6668450 . 12 .
• Russell DW . 2003 . The enzymes, regulation, and genetics of bile acid synthesis . Annu. Rev. Biochem. . 72 . 137 - 74 . 12543708 . 10.1146/annurev.biochem.72.121801.161712 .
• Falany CN, Johnson MR, Barnes S, Diasio RB . 1994 . Glycine and taurine conjugation of bile acids by a single enzyme Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase . J. Biol. Chem. . 269 . 19375 - 9 . 8034703 . 30 .