Prolactin-releasing peptide receptor explained

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PrRPR is a G-protein coupled receptor^[1] that binds the prolactin-releasing peptide (PRLH).^[2]

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary.^[3]

Further reading

• Hinuma S, Onda H, Fujino M . The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors. . J. Mol. Med. . 77 . 6 . 495–504 . 1999 . 10475064 . 10.1007/s001090050403 . 19633923 .
• Marchese A, Heiber M, Nguyen T, etal . Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. . Genomics . 29 . 2 . 335–44 . 1996 . 8666380 . 10.1006/geno.1995.9996 .
• Hinuma S, Habata Y, Fujii R, etal . A prolactin-releasing peptide in the brain. . Nature . 393 . 6682 . 272–6 . 1998 . 9607765 . 10.1038/30515 . 1998Natur.393..272H . 4306854 .
• Fujii R, Fukusumi S, Hosoya M, etal . Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. . Regul. Pept. . 83 . 1 . 1–10 . 1999 . 10498338 . 10.1016/S0167-0115(99)00028-2 . 45945978 .
• Langmead CJ, Szekeres PG, Chambers JK, etal . Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. . Br. J. Pharmacol. . 131 . 4 . 683–8 . 2000 . 11030716 . 10.1038/sj.bjp.0703617 . 1572376 .
• Lin SH, Arai AC, Wang Z, etal . The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. . Mol. Pharmacol. . 60 . 5 . 916–23 . 2001 . 11641419 . 10.1124/mol.60.5.916.
• Ozawa A, Yamada M, Satoh T, etal . Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. . Mol. Endocrinol. . 16 . 4 . 785–98 . 2002 . 11923475 . 10.1210/me.16.4.785 . free .
• Takahashi K, Totsune K, Murakami O, etal . Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas. . Peptides . 23 . 6 . 1135–40 . 2003 . 12126742 . 10.1016/S0196-9781(02)00046-3 . 24182099 .
• Kemp DM, Lin JC, Ubeda M, Habener JF . NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region. . FEBS Lett. . 531 . 2 . 193–8 . 2002 . 12417311 . 10.1016/S0014-5793(02)03502-0 . 31889191 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bhattacharyya S, Luan J, Challis B, etal . Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. . Diabetes . 52 . 5 . 1296–9 . 2003 . 12716769 . 10.2337/diabetes.52.5.1296 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ellacott KL, Donald EL, Clarkson P, etal . Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor. . Peptides . 26 . 4 . 675–81 . 2005 . 15752583 . 10.1016/j.peptides.2004.11.020 . 2717651 .
• Lagerström MC, Fredriksson R, Bjarnadóttir TK, etal . Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. . Genomics . 85 . 6 . 688–703 . 2005 . 15885496 . 10.1016/j.ygeno.2005.02.007 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

External links

• Web site: Prolactin-Releasing Peptide Receptor . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303193810/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3018 . dead .

Notes and References

1. Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P . Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors . Genomics . 29 . 2 . 335–44 . 1995 . 8666380 . 10.1006/geno.1995.9996.
2. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M . A prolactin-releasing peptide in the brain . Nature . 393 . 6682 . 272–6 . 1998 . 9607765 . 10.1038/30515 . 1998Natur.393..272H . 4306854 .
3. Web site: Entrez Gene: PRLHR prolactin releasing hormone receptor.