Procollagen glucosyltransferase explained

Procollagen glucosyltransferase
Ec Number:	2.4.1.66
Cas Number:	9028-08-4

In enzymology, a procollagen glucosyltransferase is an enzyme that catalyzes the chemical reaction

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

\rightleftharpoons UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Thus, the two substrates of this enzyme are UDP-glucose and 5-(D-galactosyloxy)-L-lysine-procollagen, whereas its two products are UDP and 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase. Other names in common use include galactosylhydroxylysine glucosyltransferase, collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, UDP-glucose-collagenglucosyltransferase, and uridine diphosphoglucose-collagen glucosyltransferase.

References

• Bosmann HB, Eylar EH . 1968 . Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase . Biochem. Biophys. Res. Commun. . 30 . 89 - 94 . 5637038 . 10.1016/0006-291X(68)90717-1 . 1 .
• Bosmann HB, Eylar EH . 1968 . Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses . Nature . 218 . 582 - 3 . 4968368 . 10.1038/218582a0 . 5141 .
• Butler WT, Cunningham LW . 1966 . Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen . J. Biol. Chem. . 241 . 3882 - 8 . 4288358 . 17 . 10.1016/S0021-9258(18)99789-9 . free .
• Kivirikko KI . Myllyla R . Collagen Glycosyltransferases . Hall, D.A. . Jackson, D.S. . International Review of Connective Tissue Research . 8 . Academic Press . New York . 1979 . 23. 10.1016/B978-0-12-363708-6.50008-4 . 389860 . 9780123637086 .