Procollagen C-endopeptidase explained

Procollagen C-endopeptidase
Ec Number:	3.4.24.19
Cas Number:	68651-95-6

Procollagen C-endopeptidase (procollagen C-terminal proteinase, carboxyprocollagen peptidase, procollagen C-terminal peptidase, procollagen C-proteinase, procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III

This endopeptidase belongs to the peptidase family M12 (astacin family).

Notes and References

1. Hojima Y, van der Rest M, Prockop DJ . Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization . The Journal of Biological Chemistry . 260 . 29 . 15996–6003 . December 1985 . 3905801 .
2. Kessler E, Adar R . Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein . European Journal of Biochemistry . 186 . 1-2 . 115–21 . December 1989 . 2689170 . 10.1111/j.1432-1033.1989.tb15184.x . free .