Prenylcysteine oxidase explained

prenylcysteine oxidase
Ec Number:	1.8.3.5
Go Code:	0001735

In enzymology, a prenylcysteine oxidase is an enzyme that catalyzes the chemical reaction

an S-prenyl-L-cysteine + O₂ + H₂O

\rightleftharpoons a prenal + L-cysteine + H₂O₂

The 3 substrates of this enzyme are S-prenyl-L-cysteine, O₂, and H₂O, whereas its 3 products are prenal, L-cysteine, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with oxygen as acceptor. The systematic name of this enzyme class is S-prenyl-L-cysteine:oxygen oxidoreductase. This enzyme is also called prenylcysteine lyase.

Human protein and gene

• Prenylcysteine oxidase 1, symbol PCYOX1, gene on chromosome 2

See also

• Hemithioacetals in nature, for mechanism of action
• Flavin adenine dinucleotide, cofactor of the enzyme
• Prenylation, a process forming S-prenyl-L-cysteine

References

• Zhang L, Tschantz WR, Casey PJ . 1997 . Isolation and characterization of a prenylcysteine lyase from bovine brain . J. Biol. Chem. . 272 . 23354 - 9 . 9287348 . 10.1074/jbc.272.37.23354 . 37 . free .
• Tschantz WR, Digits JA, Pyun HJ, Coates RM, Casey PJ . 2001 . Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase . J. Biol. Chem. . 276 . 2321 - 4 . 11078725 . 10.1074/jbc.C000616200 . 4 . free .