Pregnenolone succinate explained

Pregnenolone succinate (; brand names Panzalone, Formula 405; also known as pregnenolone hemisuccinate or pregn-5-en-3β-ol-20-one 3β-(hydrogen succinate)) is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and anti-inflammatory drug and has been patented and marketed as a topical medication in the form of a cream for the treatment of allergic, pruritic, and inflammatory dermatitis.^{[1] [2] [3]} It has also been described as a non-hormonal sterol, having neurosteroid activity, and forming a progesterone analogue via dehydrogenation.^[4]

In addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the GABA_A receptor and a positive allosteric modulator of the NMDA receptor similarly to pregnenolone sulfate.^{[5] [6] [7] [8]}

See also

• Pregnenolone acetate
• Prebediolone acetate

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 666–.
2. Book: Negwer M, Scharnow HG . Organic-chemical drugs and their synonyms: (an international survey). 4 October 2001. Wiley-VCH. 978-3-527-30247-5. 2649. 3β-Hydroxypregn-5-en-20-one hydrogen succinate = (3β)-3-(3-Carboxy-1-oxo-propoxy)pregn-5-en-20-one. S: Formula 405. Panzalone. Pregnenolone succinate. U: Glucocorticoid (anti-inflammatory, anti-allergic)..
3. Book: De Navarre MG . The chemistry and manufacture of cosmetics. 1988. Van Nostrand. 631. 9780931710162 . Pregnenolone hemisuccinate has been patented for topical use in alleviating allergic, pruritic and inflammatory dermatitis (29)..
4. Book: Milne GW . Drugs: Synonyms and Properties: Synonyms and Properties. 8 May 2018. Taylor & Francis. 978-1-351-78989-9. 1408–.
5. Book: Gibbs TT, Farb DH . Direct Modulation of Amino Acid Receptors by Neuroactive Steroids: Physiological and Pharmacological Implications. Smith SS . Neurosteroid Effects in the Central Nervous System: The Role of the GABA-A Receptor. https://books.google.com/books?id=00JbUu4lLsgC&pg=PA344. 27 October 2003. CRC Press. 978-0-203-50816-9. 344,356.
6. Irwin RP, Lin SZ, Rogawski MA, Purdy RH, Paul SM . Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies . The Journal of Pharmacology and Experimental Therapeutics . 271 . 2 . 677–682 . November 1994 . 7965782 .
7. Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH . Neurosteroid modulation of recombinant ionotropic glutamate receptors . Brain Research . 803 . 1–2 . 153–160 . August 1998 . 9729352 . 10.1016/s0006-8993(98)00644-1 . 41180982 . free .
8. Shirakawa H, Katsuki H, Kume T, Kaneko S, Ito J, Akaike A . Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons . European Journal of Pharmacology . 454 . 2–3 . 165–175 . November 2002 . 12421643 . 10.1016/s0014-2999(02)02493-7 .