Precorrin-6Y C5,15-methyltransferase (decarboxylating) explained

precorrin-6Y C5,15-methyltransferase (decarboxylating)
Ec Number:	2.1.1.132
Go Code:	0046025

In enzymology, a precorrin-6Y C5,15-methyltransferase (decarboxylating) is an enzyme that catalyzes the chemical reaction

2 S-adenosyl-L-methionine + precorrin-6Y

\rightleftharpoons 2 S-adenosyl-L-homocysteine + precorrin-8X + CO₂

The two substrates of this enzyme are S-adenosyl methionine and precorrin 6Y; its three products are S-adenosylhomocysteine, precorrin 8X, and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating). Other names in common use include precorrin-6 methyltransferase, precorrin-6Y methylase and CobL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in aerobic bacteria.

See also

• Cobalamin biosynthesis

References

• Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J . 1992 . Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product . J. Bacteriol. . 174 . 1050 - 2 . 1732195 . 3 . 206191 .