Precorrin-6A reductase explained

precorrin-6A reductase
Ec Number:	1.3.1.54
Cas Number:	137672-84-5
Go Code:	0016994

In enzymology, a precorrin-6A reductase is an enzyme that catalyzes the chemical reaction

precorrin-6A + NADPH + H⁺

\rightleftharpoons precorrin-6B + NADP⁺

The three substrates of this enzyme are precorrin 6A, NADPH and a proton; its two products are precorrin 6B and NADP⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH=CH group of an acceptor with NAD or NADPH as donor. The systematic name of this enzyme class is precorrin-6B:NADP+ oxidoreductase. Other names in common use include precorrin-6X reductase, precorrin-6Y:NADP+ oxidoreductase and CobK. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in aerobic bacteria.

See also

• Cobalamin biosynthesis

References

• Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J . 1992 . Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene . J. Bacteriol. . 174 . 1036 - 42 . 1732193 . 3 . 206185 .
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC . 2002 . The biosynthesis of adenosylcobalamin (vitamin B12) . Nat. Prod. Rep. . 19 . 390 - 412 . 12195810 . 10.1039/b108967f . 4 .