| Symptoms: | Numbness, discoloration, absent pulses, coolness |
| Complications: | Distal artery stenosis, limb amputation, arterial thromboembolism |
| Duration: | Chronic |
| Causes: | Congenital or functional |
| Risks: | Young athlete males. |
| Treatment: | Open surgical decompression |
| Prognosis: | Favorable |
The popliteal artery entrapment syndrome (PAES) is an uncommon pathology that occurs when the popliteal artery is compressed by the surrounding popliteal fossa myofascial structures. This results in claudication and chronic leg ischemia. This condition mainly occurs more in young athletes than in the elderlies. Elderlies, who present with similar symptoms, are more likely to be diagnosed with peripheral artery disease with associated atherosclerosis. Patients with PAES mainly present with intermittent feet and calf pain associated with exercises and relieved with rest. PAES can be diagnosed with a combination of medical history, physical examination, and advanced imaging modalities such as duplex ultrasound, computer tomography, or magnetic resonance angiography. Management can range from non-intervention to open surgical decompression with a generally good prognosis. Complications of untreated PAES can include stenotic artery degeneration, complete popliteal artery occlusion, distal arterial thromboembolism, or even formation of an aneurysm.
In 1879, the syndrome was first described in a 64 years old male by Anderson Stuart, a medical student.[1] In 1959, Hamming and Vink first described the management of the PAES in a 12-year-old patient. The patient was treated with myotomy of the medial head of the gastrocnemius muscle and concomitant endarterectomy of the popliteal artery. They later reported four more cases and claimed that the incidence of this pathology in patients younger than 30 years old with claudication was 40%. Servello was the first to draw attention to diminished distal pulses observed with forced plantar- or dorsiflexion in patients with this syndrome.[2] In 1981, Bouhoutsos and Daskalakis reported 45 cases of this syndrome in a population of 20,000 Greek soldiers.[3] Over the last few decades, the increasing frequency with which popliteal artery entrapment is reported, strongly suggests greater awareness of the syndrome.[4]
In the general population, popliteal artery entrapment syndrome (PAES) has an estimated prevalence of 0.16%.[5] It is most commonly found in young, physically active males.[6] In fact, sixty percent of all cases of this syndrome occur in athletically active males under the age of 30.[7] The predilection of this syndrome presents in a male to female ratio of 15:1. This discrepancy in prevalence may be overestimated due the findings that males are generally found to be more physically active than females or because a large portion of the data is from military hospitals that treat mostly male populations. People, who participate in running, soccer, football, basketball, or rugby, are at increased risk.[8]
Newborns and young children are also at increased PAES risk due to congenital causes. During embryonic development, the medial head of gastrocnemius migrates medially and superiorly. This migration can cause structural abnormalities, such as irregular positioning of the popliteal artery, and can account for the rare instances of entrapment caused by the popliteus muscle. Less than 3% of all people are born with this anatomical defect that progresses into PAES, and of those who are born with the anatomical defect, the majority never develop symptoms. Bilateral presentation of PAES is found in approximately 30% of cases.[9]
PAES can be classified as either congenital or functional.[10] Analysis of human embryological development has shown that the popliteal artery and the medial head of the gastrocnemius muscle arise at approximately the same time. Because of that, abnormal development of muscle's position in relation to the nearby vessels can result in potential vascular compromise. The varying types of PAES can be classified based on aberrant migration and resultant attachments of the medial head of the gastrocnemius muscle. Type VI PAES (functional PAES) describes a subtype that is due to repeated microtrauma resulting in the destruction of the internal elastic lamina and damage to the smooth muscles resulting in fibrosis and scar formation.
| The popliteal artery courses more medially around a normally positioned medial head of the gastrocnemius muscle. | ||
| Type II | The medial head of the gastrocnemius muscle attaches more laterally to the femur. | |
| Type III | Aberrant additional tendon of the gastrocnemius muscle encircles a normally positioned popliteal artery. | |
| Type IV | The popliteal artery is compressed by the popliteus muscle or a fibrous brand. | |
| Type V | The compression of both the popliteal artery and vein by any of the above causes. | |
| Type VI | The normally positioned popliteal artery is entrapped by the gastrocnemius muscle hypertrophy. |
Patients with PAES are typically healthy young males without previous history of cardiovascular risk factors such as smoking, hypertension, hypercholesterolemia, or diabetes. Typically, patients present with intermittent claudication that is worsened with exercise and relieved with rest. Associated symptoms include numbness, discoloration, pallor, and coolness in the affected lower extremity. Physical examination of suspected PAES may show hypertrophy of the calf muscles, as well as diminished, unequal, or absent pulses in the lower extremity upon plantar- or dorsiflexion.[12]
PAES should be suspected in young healthy male patients with clinical symptoms consistent with compression of the vascular structures and without significant cardiovascular risk factors such as smoking. Multiple imaging modalities are used to confirm the diagnosis of PAES.[18] Based on a systemic review by Sinha et al, digital subtraction angiography (DSA) is the most common imaging used for PAES diagnosis, followed by ankle–brachial index (18 percent), computed tomography angiography (CTA) (12 percent), magnetic resonance angiography (MRA) (12 percent), duplex ultrasonography (DU) (10 percent), exercise ankle-brachial index (4 percent), and other modalities (4 percent). According to a recent study by Willimas et al, a combination of DU and MRA is far superior in diagnosing PAES.[19]
Provocative maneuvers can be used to improve visualization of PAES on the imagines.[20] The patient is initially positioned supine with the legs straight, and then instructed to forcefully plantar-flex. A plantarflexion force of 0 to 70 percent maximum has been shown to maximize the sensitivity and specificity for PAES diagnosis. The DU can be a quick, inexpensive, and noninvasive initial screening for PAES. Flow velocities in the popliteal artery will increase, as the popliteal artery is compressed, which is reflected on the DU. If DU is negative but there is still strong suspicion for PAES, MRA or CTA with provocative maneuvers are needed as follow-up imaging. MRA would demonstrate a focal occlusion or narrowing of the mid-popliteal artery, post-stenotic dilatation, or aneurysm of the distal popliteal artery. If MRA or CTA is non-conclusive, DSA may be used as a further option with a high sensitivity (> 97%) for PAES diagnosis.
Additionally, functional PAES in which the gastrocnemius hypertrophy causes arterial compression during exercise can be best evaluated with dynamic CT. For dynamic CT, initial images are taken with the patient still. Further images are taken following a series of provocative maneuvers.
The outcome following the surgery is usually favorable. Successful resolution of PAES occurs in 77 percent of cases. Surgical complications include deep vein thrombosis, hematoma, wound infection, or seroma. After the surgery, patient is usually monitored using arterial duplex ultrasonography 1, 3, 6, and 12 months, and annually after that.
Early detection and management of PAES can lead to a favorable outcome. However, prolonged compression of popliteal artery can lead to extensive arterial damage and permanent claudication or limb loss.[24] Complications of PAES may include:
Nonetheless, the course of PAES is often slow and takes time, thus, limbs loss is rarely seen, even in PAES patients.