Polypyrimidine tract-binding protein explained

polypyrimidine tract binding protein 1
Hgncid:	9583
Symbol:	PTBP1
Altsymbols:	PTB
Entrezgene:	5725
Omim:	600693
Refseq:	NM_002819
Uniprot:	P26599
Chromosome:	19
Arm:	p
Band:	13.3

polypyrimidine tract binding protein 2
Hgncid:	17662
Symbol:	PTBP2
Entrezgene:	58155
Omim:	608449
Refseq:	NM_021190
Uniprot:	Q9UKA9
Chromosome:	1
Arm:	p
Band:	21.3
Locussupplementarydata:	-22.1

Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.^[1] Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.^{[2] [3]} These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.

See also

• Polypyrimidine tract

Notes and References

1. Valcárcel J, Gebauer F . 13820693 . Post-transcriptional regulation: the dawn of PTB . Current Biology . 7 . 11 . R705-8 . November 1997 . 9382788 . 10.1016/S0960-9822(06)00361-7 . free . 1997CBio....7R.705V .
2. Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, Tang C, Liu F, Wang L, Feng C, Liu M, Li S, Zhang Y, Xu H, Yao H, Shi L, Yang H . 215514410 . Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice . Cell . 181 . 3 . 590–603.e16 . April 2020 . 32272060 . 10.1016/j.cell.2020.03.024 . free .
3. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD . 220051280 . Reversing a model of Parkinson's disease with in situ converted nigral neurons . Nature . 582 . 7813 . 550–556 . June 2020 . 32581380 . 7521455. 10.1038/s41586-020-2388-4 . 2020Natur.582..550Q .