Polypeptide N-acetylgalactosaminyltransferase explained

polypeptide N-acetylgalactosaminyltransferase
Ec Number:	2.4.1.41
Cas Number:	9075-15-4
Go Code:	0004653

In enzymology, a polypeptide N-acetylgalactosaminyltransferase is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + polypeptide

\rightleftharpoons UDP + N-acetyl-D-galactosaminyl-polypeptide

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and calcium.

Nomenclature

The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include:

• protein-UDP acetylgalactosaminyltransferase,
• UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase,
• UDP-N-acetylgalactosamine:kappa-casein polypeptide,
• N-acetylgalactosaminyltransferase,
• uridine diphosphoacetylgalactosamine-glycoprotein,
• acetylgalactosaminyltransferase,
• glycoprotein acetylgalactosaminyltransferase,
• polypeptide-N-acetylgalactosamine transferase,
• UDP-acetylgalactosamine-glycoprotein,
• acetylgalactosaminyltransferase,
• UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase,
• UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase,
• UDP-N-acetyl-alpha-D-galactosamine:polypeptide,
• N-acetylgalactosaminyltransferase,
• UDP-N-acetylgalactosamine-glycoprotein,
• N-acetylgalactosaminyltransferase,
• UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase,
• UDP-N-acetylgalactosamine:polypeptide,
• N-acetylgalactosaminyltransferase, and
• UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase.

References

• Sugiura M, Kawasaki T, Yamashina I . 1982 . Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66 . J. Biol. Chem. . 257 . 9501 - 7 . 6809738 . 16 .
• Takeuchi M, Yoshikawa M, Sasaki R, Chiba H . 1985 . Purification and characterization of UDP-N-acetylgalactosamine-kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow . Agric. Biol. Chem. . 49 . 4 . 1059 - 1069 . 10.1271/bbb1961.49.1059. free .